Bacterial multidrug efflux pumps: Mechanisms, physiology and pharmacological exploitations
نویسندگان
چکیده
منابع مشابه
Biochemistry of Bacterial Multidrug Efflux Pumps
Bacterial pathogens that are multi-drug resistant compromise the effectiveness of treatment when they are the causative agents of infectious disease. These multi-drug resistance mechanisms allow bacteria to survive in the presence of clinically useful antimicrobial agents, thus reducing the efficacy of chemotherapy towards infectious disease. Importantly, active multi-drug efflux is a major mec...
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Bacterial multidrug efflux pumps are antibiotic resistance determinants present in all microorganisms. With few exceptions, they are chromosomally encoded and present a conserved organization both at the genetic and at the protein levels. In addition, most, if not all, strains of a given bacterial species present the same chromosomally-encoded efflux pumps. Altogether this indicates that multid...
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Evolution by natural selection and the overuse of antibiotics have led to the emergence and proliferation of drug-resistant bacteria. One of the mechanisms that bacteria have evolved to overcome antibiotics is the membrane efflux pump. By expelling the drugs outside of the cell, the bacterium prevents the molecule from accumulating to a toxic level. Transcriptional regulators, which control whe...
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Antimicrobial resistance represents a significant challenge to future healthcare provision. An acronym ESKAPEE has been derived from the names of the organisms recognised as the major threats although there are a number of other organisms, notably Neisseria gonorrhoeae, that have become equally challenging to treat in the clinic. These pathogens are characterised by the ability to rapidly devel...
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Bacterial multidrug resistance (MDR) efflux pumps are an important mechanism of antibiotic resistance and are required for many pathogens to cause infection. They are also being harnessed to improve microbial biotechnological processes, including biofuel production. Therefore, scientists of many specialties must be able to accurately measure efflux activity. However, myriad methodologies have b...
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ژورنال
عنوان ژورنال: Biochemical and Biophysical Research Communications
سال: 2014
ISSN: 0006-291X
DOI: 10.1016/j.bbrc.2014.05.090